Toll/interleukin-1 receptor adapter protein (TIRAP)

Details Toll/interleukin-1 receptor adapter protein (TIRAP) Toll/interleukin-1 receptor adapter protein (TIRAP)

2005-11-01

2005-11-01

Wax, Robert A. (Department: 1651)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

C514S012200, C530S324000, C435S069700

Reexamination Certificate

active

06960343

ABSTRACT:
TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and polynucleotides in therapy, and diagnostic assays for such.

REFERENCES:
patent: 2002/0164640 (2002-11-01), Sims et al.
patent: 1 142 472 (2001-10-01), None
patent: WO 99/47150 (1999-09-01), None
patent: WO 00/41561 (2000-07-01), None
patent: WO 00/60080 (2000-10-01), None
patent: WO 01/88137 (2001-11-01), None
Result 7 of sequence search in Geneseq database, alignment with Seq ID No: 11 of DE 19526174 A1, printed on Apr. 26, 2005.
Result 1 of sequence search in US issued patents database, alignment with SEQ ID No: 2 of U.S. Appl. No. 6,399,584, printed on Apr. 26, 2005.
Hardiman, Gary, et al., “Genetic Structure and Chromosomal Mapping of MyD88,”Genomics, 45(2):332-339 (Oct. 15, 1997).
Hattori, M., “Homo Sapiens Genomic DNA, Chromosome 11 Clone: RP11-712L6, incomplete sequence,” XP002303401, Database EMBL Accession No. AP001318 (Mar. 6, 2000).
Horng, Tiffany, et al., “TIRAP: An Adapter Molecule in the Toll Signaling Pathway,”Nature Immunology, 2(9): 835-841 (Sep., 2001).
Means, T.K., et al., “Differential Effects of a Toll-Like Receptor Antagonist onMycobacterium Tuberculosis-Induced Macrophage Responses,”Journal of Immunology, 166(6):4074-4082 (Mar. 15, 2001).
Bonnert, T.P., et al., “The cloning and characterization of human MyD88: a member of an IL-1 receptor related family”, FEBS Lett., 1997, 402 (1), 81-84.
Fitzgerald, K.A., “Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction”, 2001 Nature 413 (6851), 78-83.
GenBank Accession No. AAB49967.
GenBank Accession No. AAB83958.
GenBank Accession No. AAC50954.
GenBank Accession No. AAC53013.
GenBank Accession No. AAH05584.
GenBank Accession No. AAH05591.
GenBank Accession No. AAH13589.
GenBank Accession No. AAL05037.
GenBank Accession No. AX320365.
GenBank Accession No. CAA35762.
GenBank Accession No. CAD19393.
GenBank Accession No. NP_002459.
GenBank Accession No. NP_034981.
GenBank Accession No. P22366.
GenBank Accession No. P58753.
GenBank Accession No. Q99836.
GenBank Accession No. Q99JY1.
GenBank Accession No. S11226.
GenBank Accession No. XP_087468.
Hardiman, et al., “Molecular characterization and modular analysis of humanMyD88”, 1996, Oncogene 13 (11), pp. 2467-2475.
Horng, T., “TIRAP: an adapter molecule in the Toll signaling pathway”, 2001, Nat. Immunol. 2 (9), 835-841.
Lord, et al., “Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6”, 1990, Oncogene 5 (7), 1095-1097.
Fitzgerald et al. Mal.(MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Nature. Sep. 2001, vol. 413, pp. 78-83.
Bonnert et al. The cloning and characterization of human MYD88: a member of an IL-1 receptor related family. FEBS Letters. 1997, vol. 402, pp. 81-84.
Sigmund et al. Viewpoint: Are studies in genetically altered mice out of control? Arterioscler. Thromb. Vasc. Biol. 2000, vol. 20, pp. 1428-1429.

Affiliated with

Also associated with

Rating

Toll/interleukin-1 receptor adapter protein (TIRAP) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Toll/interleukin-1 receptor adapter protein (TIRAP), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Toll/interleukin-1 receptor adapter protein (TIRAP) will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3506064