Tolerizing and desensitizing compounds, compositions and methods

Details Tolerizing and desensitizing compounds, compositions and methods Tolerizing and desensitizing compounds, compositions and methods

1979-05-31

1984-01-31

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424101, 560144, A61K 3122, C07C 6900

Patent

active

044289650

ABSTRACT:
Compounds, compositions and a method of treatment to tolerize and desensitize mammals sensitive to the allergenic moities found in plants of the Anacardiaceae and Ginkgoaceae families comprising the reaction product of poison ivy urushiol, poison oak urushiol, poison sumac urushiol & mixtures thereof, 3-n-alkane substituted catechol derivatives having 11 to 19 carbon atoms and the unsaturated olefinic congeners thereof with an acyl ester functioning group esterifying the catecholic hydroxy constituents of the aforementioned compounds or cell membrane residues.

REFERENCES:
patent: 2833825 (1958-05-01), Lewis
patent: 3294836 (1966-12-01), Peterson et al.
patent: 3624135 (1971-11-01), Kablaoui
patent: 3631227 (1971-12-01), Kablaoui et al.
The Merk Index-9th Ed., p. 9553, (1976).
Hill et al., J. Am. Chem. Soc. 56: 2736 (1934).
Srinivasan et al., Analytical Biochemistry, 6: 234 (1963).

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