Tolerance of trichothecene mycotoxins in plants through the...

Multicellular living organisms and unmodified parts thereof and – Plant – seedling – plant seed – or plant part – per se – Higher plant – seedling – plant seed – or plant part

Reexamination Certificate

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C435S320100, C536S023600, C800S279000, C800S298000

Reexamination Certificate

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06855872

ABSTRACT:
Fusarium graminearumis a plant pathogen, attacking a wide range of plant species including corn (ear and stalk rot), barley, and wheat (head blight).Fusariumepidemics result in millions of dollars of losses in crop revenues.Fusarium graminearuminfection in the cereals reduces both grain yield and quality. Mycotoxins are produced by many fungalFusariumspecies and thus the grain becomes contaminated with these mycotoxins, such as the trichothecenes. The major trichothecene produced byF. graminearumis deoxynivalenol (abbreviated as DON, also known as vomitoxin). Trichothecenes are potent protein synthesis inhibitors and are quite toxic to humans and livestock. A yeast gene has been identified which confers upon yeast tolerant of the trichothecene, trichodermin. A corresponding plant gene has been prepared, which has been used to transform plants. These transformed plants have an increased resistance toFusariuminfestation.

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