Tocotrienols in the treatment of hypercholesterolemia, hyperlipi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514824, A61K 31355

Patent

active

052179923

ABSTRACT:
This invention relates to the use of tocotrienol, gamma-tocotrienol and delta-tocotrienol in reducing hypercholesterolemia, hyperlipidemia and thromboembolic disorders in mammals. [The isolation of these tocotrienols from natural sources and their chemical synthesis is disclosed.] The chemical synthesis of these tocotrienols is disclosed. The present invention also relates to prodrugs and pharmaceutical compositions of gamma-tocotrienol, delta-tocotrienol and tocotrienol and uses thereof.

REFERENCES:
patent: 4603142 (1986-07-01), Burger et al.
patent: 4617406 (1986-10-01), Willging
Tan, Barrie; JAOCS vol. 66(6) Jun. 1989 pp. 770-776.
Qureshi, et al. Atherosclerosis, 51: 75-87, (1984).
Qureshi, et al., J. Biol. Chem., 261: 10544-10550, (1986).
Whittle, et al., Biochem. J., 100: 138-145, (1966).
Pennock, et al., Biochem. and Biophys. Pres. Comm., 17: 542-548, (1964).
Scott, et al., Helv. Chim. Acta, 59: 290-306 (1976).
Urano, et al., Chem. Pharm. Bull., 31: 4341-4345 (1983).
Komiyama, et al., Chem. Pharm. Bull., 37: 1369-1371 (1989).
Hirahara, Nutrition Reports International, 36: 161-167 (1987).
Kato, et al., Yukagaku, 30: 590-591 (1981).

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