Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-12-25
2007-12-25
Jiang, Shaojia Anna (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S458000, C549S404000, C549S405000, C549S407000, C549S408000, C549S412000, C549S413000
Reexamination Certificate
active
10644418
ABSTRACT:
The present invention provides an antiproliferative compound having the structural formulawherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound having said structural formula.
REFERENCES:
patent: 3869477 (1975-03-01), Shindo et al.
patent: 4181725 (1980-01-01), Voorhees et al.
patent: 4320141 (1982-03-01), Komatsu et al.
patent: 4457918 (1984-07-01), Holick et al.
patent: 4617317 (1986-10-01), Bennet
patent: 4645845 (1987-02-01), Gehrken et al.
patent: 4665204 (1987-05-01), Wirth
patent: 4873088 (1989-10-01), Mayhew et al.
patent: 4895719 (1990-01-01), Radhakrishnan et al.
patent: 5114957 (1992-05-01), Hendler et al.
patent: 5135945 (1992-08-01), Robinson et al.
patent: 5260294 (1993-11-01), Walser
patent: 5315017 (1994-05-01), Le Baut et al.
patent: 5393775 (1995-02-01), Le Baut et al.
patent: 5403834 (1995-04-01), Malfroy-Camine et al.
patent: 5480645 (1996-01-01), Della Valle et al.
patent: 5545660 (1996-08-01), Grisar et al.
patent: 5610180 (1997-03-01), Fariss
patent: 5650404 (1997-07-01), Ogata et al.
patent: 5747162 (1998-05-01), Temple et al.
patent: 5780445 (1998-07-01), Schneider et al.
patent: 5827878 (1998-10-01), Makishima et al.
patent: 5915818 (1999-06-01), Tazawa et al.
patent: 5917060 (1999-06-01), Rosenau et al.
patent: 5919818 (1999-07-01), Lane et al.
patent: 5990322 (1999-11-01), Lee et al.
patent: 6022560 (2000-02-01), Yazdi et al.
patent: 6127382 (2000-10-01), Beard et al.
patent: 6133312 (2000-10-01), Elson
patent: 6417223 (2002-07-01), Sanders et al.
patent: 6645998 (2003-11-01), Sanders et al.
patent: 6770672 (2004-08-01), Sanders et al.
patent: 2003/0236301 (2003-12-01), Sanders et al.
patent: 2004/0097431 (2004-05-01), Sanders et al.
patent: 4304303 (2004-08-01), None
patent: 0436911 (1990-07-01), None
patent: 0506048 (1992-09-01), None
patent: 0636618 (1995-02-01), None
patent: 0751125 (1997-01-01), None
patent: 0754458 (1997-02-01), None
patent: 0768314 (1997-04-01), None
patent: 55076871 (1980-06-01), None
patent: 63303049 (1988-12-01), None
patent: 01041727 (1989-02-01), None
patent: 04229269 (1992-08-01), None
patent: 9301969 (1997-11-01), None
patent: 1997301969 (1997-11-01), None
patent: WO 97/41852 (1997-11-01), None
patent: WO 98/17246 (1998-04-01), None
patent: WO 99/24417 (1999-05-01), None
patent: WO 00/16772 (2000-03-01), None
patent: WO 01/58889 (2001-08-01), None
patent: WO 03/039461 (2003-05-01), None
Balis, F. “Evolution of anticancer drug discovery and the role of cell-based screening” J. Natl. Cancer Inst. (2002) vol. 94, No. 2, pp. 78-79.
Kerbel, R. “What is the optimal rodent model for anti-tumor drug testing?” Cancer and Metastasis (1999) vol. 17, pp. 301-304.
Monks, A. et al “The NCI anti-cancer drug screen . . . ” Anti-Cancer Drug Design (1997) vol. 12, pp. 533-541.
Burke et al., “Effects of topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice,”Nutrition and Cancer, 38(1):87-97, 2000.
Fabiani et al., “Antioxidants prevent the lymphocyte DNA damage induced by PMA-stimulated monocytes,” Nutrition and Cancer, 39(2):284-291, 2001.
Helzlsouer et al., “Association between α-tocopherol, γ-tocopherol, selenium, and subsequent prostate cancer,”J Nat Cancer Inst, 92(24):2018-2023, 2000.
Jiang et al., “γ-tocopherol, the major form of vitamin E in the US diet, deserves more attention,”Am J Clin Nutr, 74:714-722, 2001.
Kakizaki et al., “Effect of a α-tocopherol on hepatocarcinogensis in transforming growth factor-α (TGF-α) transgenic mice treated with diethylnitrosamine,”Int J Vitam Nutr Res, 71(5):261-267, 2001.
Malvy et al., “Effect of two years' supplementation with natural antioxidants on vitamin and trace elements status biomarkers: preliminary data of the SU.VI.MAX study,” Cancer Detection and Prevention, 25(5):479-485, 2001.
Neuzil et al., “Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role,”Redox Report, 6(3):143-151, 2001.
Schwartz, “Directed lysis of experimental cancer by β-carotene in liposomes,”Nutrition and Cancer, 16:107-124, 1991.
Schwartz, “The administration of beta carotene to prevent and regress oral carcinoma in the hamster cheek pouch and the associated enhancement of the immune response,”Adv Exp Med Biol, 262:77-93, 1990.
Schwartz, “The effect of cartenoids on the antitumor immune response tin vivo and invitro with hamster and mouse immune effectors,”Annals New York Academy of Sciences, 587:92-109, 1990.
Werninghaus et al., “Protective effect of alpha-tocopherol in carrier liposomes on ultraviolet-mediated human epidermal cell damage in vitro,”Photodermatol Photoimmunol Photomed, 8(6):236-242, 1991.
Brown et al., “Novel heteroarotinoids as potential antagonists of mycobacterium bovis BCG,”J. Med. Chem., 47:1008-1017, 2004.
Arya et al., “Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells,”Bioorg. Med. Chem. Lett., 8:2433-2438, 1998.
Djuric et al., “Growth inhibition of MCF-7 and MCF-10A human breast cells by alpha-tocopheryl hemisuccinate, cholestryl hemisuccinate and their ether analogs,”Cancer Lett., 111:133-139, 1997.
Fariss et al., “The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholestryl hemisuccinate on murine leukemia cells result from the action of the intact compounds,”Cancer Res., 54:3346-3351, 1994.
Koyama et al., “Synthesis of fluorine analogues of vitamin E. II. Synthesis of 2-(3-chloropropyl)-2,5,7,8-tetramethyl-6-chromanol and its application for stereocontrolled Witting reaction with trifluoromethyl ketones,” Chem. Pharm. Bull., 36:2950-2954. 1988.
Prasad et al., “Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture,”Cancer Res., 42:550-555, 1982.
Urano et al., “Synthesis of dl-α-tocopherol and dl-α-tocotrienol,”Chem. Pharm. Bull., 31:4341-4345, 1983.
Welch et al., “Syntheses and activities of antioxidant derivatives of retinoic acids,”J. Med. Chem., 25:81-84, 1981.
Will et al., “Attachment of vitamin E derivatives to oligonucleotides during solid-phase synthesis,”Tetrahedron Lett. 33:2729-2732, 1992.
Gardner Robb
Hurley Laurence
Israel Karen
Kline Kimberly
Liu Shenquan
Fulbright & Jaworski L.L.P.
Jiang Shaojia Anna
Olson Eric S
Research Development Foundation
LandOfFree
Tocopherols, tocotrienols, other chroman and side chain... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tocopherols, tocotrienols, other chroman and side chain..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tocopherols, tocotrienols, other chroman and side chain... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3853796