Tocopherol derivatives and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S397000, C514S394000, C548S305100, C548S311400

Reexamination Certificate

active

07732617

ABSTRACT:
Tocopherol derivatives having the general formula:wherein n is an integer of 6 to 13, R1is hydrogen, a silyl ether or acetate, R2is an optionally substituted nitrogen-containing heterocycle or a polycyclic nitrogen-containing heterocycle; and pharmaceutically acceptable salts thereof are provided. A method for synthesizing the compounds is also provided. The tocopherol derivatives are capable of inhibiting the primary enzyme responsible for the metabolism of the tocopherols and tocotrienols compounds of vitamin E, namely tocopherol-ω-hydroxylase, and thus increase the amount and prolong the availability of these compounds in plasma and tissue.

REFERENCES:
patent: 0 677 520 (1995-10-01), None
patent: WO 00/01685 (2000-01-01), None
patent: WO 03/043570 (2003-05-01), None
patent: WO 2005/035491 (2005-04-01), None
patent: WO 2005/039443 (2005-05-01), None
Slide entitled “Inhibition of P450-mediated tocopherol metabolism” presented at a seminar at the University of Pittsburgh, Department of Environmental and Occupational Health, Pittsburgh, PA, US (May 25, 2006): “The Bioorganic Chemistry of Vitamin E: New Tools and Approaches (or Rancid Fat, Hand Cream, and Snake Oil)”. (print of slide enclosed).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tocopherol derivatives and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tocopherol derivatives and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tocopherol derivatives and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4181407

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.