Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-05-25
2010-06-08
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S397000, C514S394000, C548S305100, C548S311400
Reexamination Certificate
active
07732617
ABSTRACT:
Tocopherol derivatives having the general formula:wherein n is an integer of 6 to 13, R1is hydrogen, a silyl ether or acetate, R2is an optionally substituted nitrogen-containing heterocycle or a polycyclic nitrogen-containing heterocycle; and pharmaceutically acceptable salts thereof are provided. A method for synthesizing the compounds is also provided. The tocopherol derivatives are capable of inhibiting the primary enzyme responsible for the metabolism of the tocopherols and tocotrienols compounds of vitamin E, namely tocopherol-ω-hydroxylase, and thus increase the amount and prolong the availability of these compounds in plasma and tissue.
REFERENCES:
patent: 0 677 520 (1995-10-01), None
patent: WO 00/01685 (2000-01-01), None
patent: WO 03/043570 (2003-05-01), None
patent: WO 2005/035491 (2005-04-01), None
patent: WO 2005/039443 (2005-05-01), None
Slide entitled “Inhibition of P450-mediated tocopherol metabolism” presented at a seminar at the University of Pittsburgh, Department of Environmental and Occupational Health, Pittsburgh, PA, US (May 25, 2006): “The Bioorganic Chemistry of Vitamin E: New Tools and Approaches (or Rancid Fat, Hand Cream, and Snake Oil)”. (print of slide enclosed).
Atkinson Jeffrey
Nava Phillip John
Ohnmacht Stephan
Parker Robert S.
West Ryan
Brock University
Cornell University
Dennison, Schultz & MacDonald
Jaisle Cecilia M
Wilson James O
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