Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2006-05-16
2006-05-16
Rao, Manjunath (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S004000, C435S006120, C435S252300, C435S320100, C435S252800, C435S440000, C536S023200, C536S023700, C536S023400, C530S350000
Reexamination Certificate
active
07045324
ABSTRACT:
The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides that code for 30 novel amino acids that are not expressed by TAP-46. The present invention provides data showing that TAP-38 enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP reduces the effectiveness of tocopherol based compounds. Thus, the present invention claim that expression of TAP-38 by tumor cells enhances the apoptotic inducing properties of tocopherol based compounds. The present invention provides aerosol liposome/transfection/infection methods for delivery of TAP-38 and TAP-46 cDNA plasmids separately and in combination with tocopherol based apoptotic inducing agents as well as with other chemotherapeutic agents as a method for treatment and prevention of cellular proliferative diseases and disorders.
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Hantash Feras
Kline Kimberly
Liu Hui
Sanders Bob G.
Yu Weiping
Fulbright & Jaworski L.L.P.
Pak Yong D.
Rao Manjunath
Research Development Foundation
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