Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-06-10
2000-07-18
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514312, 544 92, 546158, A61K 31535, A61K 3147, C07D26512, C07D21516
Patent
active
06090805&
ABSTRACT:
This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
REFERENCES:
patent: 5652247 (1997-07-01), Ogawa et al.
patent: 5665719 (1997-09-01), Bock et al.
patent: 5726172 (1998-03-01), Sparks et al.
patent: 5756504 (1998-05-01), Bock et al.
P.D. Williams, et al., "Recent Advances in the Development of Oxytocin Receptor Antagonists" Current Pharmaceutical Design, (1996), vol. 2, pp. 41-48.
Bell Ian
Freidinger Roger M.
Perlow Debra S.
Sparks Michelle A.
Stauffer Kenneth
Durette Philippe L.
Lambkin Deborah C.
Merck & Co. , Inc.
Winokur Melvin
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