Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-02-27
1998-05-26
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 92, 546346, 546315, 546344, 546153, 546180, 546217, C07D26518, A61K 31535
Patent
active
057564973
ABSTRACT:
This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
REFERENCES:
patent: 5665719 (1997-09-01), Bork et al.
Williams et al Chem. Abstr. vol. 125, Entry 221854 (Abstracting WO 96 22775), 1996.
Serradeil-Legal et al J. Clin. Invest., (1993) 92, 224-231.
Williams et al J. Med. Chem., (1995) 38, 4634-4636.
Imaizumi et al Hypertension (1992) 20, 54-58.
Yamamura et al Science (1991), 252, 572.
Ohnishi et al J. Clin. Pharm., (1993), 33, 230-238.
Bell Ian M.
Freidinger Roger M.
Williams Peter D.
Daus Donald G.
Merck & Co. , Inc.
Winokur Melvin
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