TNF receptors, TNF binding proteins and DNAs coding for them

Details TNF receptors, TNF binding proteins and DNAs coding for them TNF receptors, TNF binding proteins and DNAs coding for them

1995-06-07

1998-12-01

Scheiner, Toni R.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

435 723, 436503, 436 64, G01N 3353, G01N 33574

Patent

active

058437916

ABSTRACT:
DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.

REFERENCES:
Carlino, J.A., et al., J. Biol. Chem., vol. 262, No. 3, pp. 958-961, Jan. 25, 1987.
Stauber, G.B., et al., J. Biol. Chem. , vol. 263, No. 35. pp. 19098-19104, Dec. 15, 1988.

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