Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-23
1999-09-07
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 235, 4353201, 435325, 4352523, 43525411, 530350, 530351, C12N 1512, C12N 510, C12N 1510, C07K 1447
Patent
active
059486384
ABSTRACT:
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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Chen Jennifer
Graham James
Lin Lih-Ling
Schievella Andrea R.
Brown Scott A.
Feisee Lila
Genetics Institute Inc.
Kaufman Claire M.
Sprunger Suzanne A.
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