TNF receptor death domain ligand proteins

Details TNF receptor death domain ligand proteins TNF receptor death domain ligand proteins

1997-04-23

1999-04-06

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 530350, 536 235, C07K 14705, C12N 1512

Patent

active

058916750

ABSTRACT:
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

REFERENCES:
patent: 5464938 (1995-11-01), Smith et al.
patent: 5506340 (1996-04-01), Heavner
patent: 5563039 (1996-10-01), Goeddel et al.
Miki et al. (1992) Cancer Res. 52:643.
Darnay et al. (1994) J. Biol. Chem. 269:20299.
Kiefer et al. (1992) J. Biol. Chem. 267:12692.
Genbank accession No. T08593 (1993).
Genbank accession No. T07800 (1993).
Genbank accession No. M78050 (1992).
Genbank accession No. M78539 (1992).
Genbank accession No. U44953 (1 Jul. 1996).
Genbank accession No. U48254 (3 Aug. 1996).
Tartaglia et al., Tumor necrosis factor receptor signaling, J. Biol. Chem., 267(7): 4304-4307, Mar. 1992.
Tartaglia et al., Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor, Cell, 73:213-216, Apr. 1993.
Schall et al., Cell 61:361-370 (1990).
Shimasaki et al., J. Biol. Chem. 266:10646-10653 (1991).
Saragovi et al., Bio/Technology 10:773-778 (1992).
McDowell et al., J. Amer. Chem. Soc. 114:9245-9253 (1992).
Kaufman et al., Nucleic Acids Res. 19:4485-4490 (1991).
Kaufman et al., Methods in Enzymology 185:537-566 (1990).
Cyuris et al., Cell 75:791-803 (1993).
Gietz et al., Nucleic Acids Res. 20:1425 (1992).
Waye et al., Protein Engineering 8:90 (1995).
Auffray et al., Life Sciences 318:263-272 (1995).
Rothe et al., Cell 78:681-692 (1994).
Song et al., The Journal of Biological Chemistry 269:22492-22495 (1994).
Tartaglia et al., Cell 74:845-853 (1993).
Boldin et al., The Journal of Biological Chemistry 270(1):387-391 (1995).
Hsu et al., Cell 81:495-504 (1995).
Boldin et al., FEBS Letters 367:39-44 (1995).

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