TNF receptor death domain ligand proteins

Details TNF receptor death domain ligand proteins TNF receptor death domain ligand proteins

1996-05-17

1998-12-08

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 435325, 4352523, 43525411, 4353201, 530350, C12N 1512, C12N 510, C12N 1563, C07K 1447

Patent

active

058470999

ABSTRACT:
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

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