TNF receptor action modulation

Details TNF receptor action modulation TNF receptor action modulation

2006-04-14

2008-09-30

Stucker, Jeffrey (Department: 1649)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S142100, C424S143100, C530S300000, C530S350000, C530S387100

Reexamination Certificate

active

07429379

ABSTRACT:
A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.

REFERENCES:
patent: 0 393 438 (1990-10-01), None
patent: 0 444 560 (1991-09-01), None
Sol et al. (1999). J virol. 73, 8762-8770.
Kuebler et al (2000). J. Clin. Invest. 105, 905-913.
Kameyama et al (2006). Bioconjugat Chem. 17, 597-602.
Schwarze et al (1999) Science. 285, 1569-1572.
Carson (1993). PNAS. 90, 7427-7428.
Aggarwal BB, “Structure of tumor necrosis factor and its receptor”,Biotherapy3(2):113-120 (1991).
Engelmann et al. “Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity”,J Biol Chem265(24):14497-14504 (1990).
Espevik et al, “Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor”,J Exp Med171(2):415-426 (1990).
Fitzgerald et al (Eds),The Cytokine Facts Book, Human TNF-R p55 and p75, p. 478 (2001).
Hwang et al, “A 20 amino acid synthetic peptide of a region from the 55 kDa human TNF receptor inhibits cytolytic and binding activities of recombinant human tumour necrosis factor in vitro”,Proc R Soc Lond B Biol Sci245(1313):115-9 (1991).
Lie et al, “Identification of the binding site of 55kDa tumor necrosis factor receptor by synthetic peptides”,Biochem Biophys Res Commun188(2):503-9 (1992).
Porteau et al, “Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils”,J Biol Chem266(28):18846-18853 (1991).
Shalaby et al, “Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors”,J Exp Med172(5):1517-20 (1990).

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