Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-04-01
1996-01-23
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 536 2351, 530351, 43525233, 4353201, C12P 2106, C07H 1700, C07K 1400, C12N 120
Patent
active
054864631
ABSTRACT:
The present invention is directed to a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof having selective binding affinity for the human p55-Tumor-Necrosis-Factor-Receptor characterized in that the amino acid sequence of human Tumor Necrosis Factor is changed at least at position 86 having a threonine instead of a serine residue, a DNA sequence coding for such a mutein, a vector comprising such a DNA sequence, and a host cell transformed by such a vector.
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Lesslauer Werner
Lotscher Hansruedi
Stuber Dietrich
Carlson K. Cochrane
Draper Garnette D.
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
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