TNF-muteins

Details TNF-muteins TNF-muteins

1991-11-20

1995-06-06

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 435 695, A61K 4505, C07K 1300, C12P 2106

Patent

active

054221048

ABSTRACT:
It is an object of this invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by a deletion, insertion, substitution or combinations thereof, of one or more amino acids so that the mutein shows a significant difference between its binding affinity to the human p75-Tumor-Necrosis-Factor-Receptor and to the human p55-Tumor-Necrosis-Factor-Receptor. The invention also includes DNA sequences coding for such muteins, vectors comprising such DNA sequences, host cells transformed with such vectors and a process for the production of such muteins employing such transformed host cells and pharmaceutical compositions containing such muteins and their use for the treatment of illnesses, for example cancer.

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