Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1990-02-27
1992-08-04
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530351, 530369, C07K 1500
Patent
active
051360217
ABSTRACT:
A TNF-inhibitory protein having a molecular weight of 28 kilodaltons and having an activity of rendering resistant to TNF a TNF- sensitive cell to thereby inhibit the cytolytic and/or cytostatic activity of TNF for the TNF-sensitive cells and a method for producing the same are described. The TNF-inhibitory protein can advantageously be used as an antigen for producing an antibody useful for detecting a patient having TNF-resistant cancer and for removing the TNF-resistance of the cancer cells of the patient.
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Purification and initial characterization of a type .beta.transforming growth factor from human placenta Charles A. Frolik et al. Proc. Natl. Acad. Sci. USA, 80: 3676-3680, 1983.
A Tumor Necrosis Factor-binding Protein Purified to Homogeneity from Human Urine, Protects Cells from Tumor Necrosis Factor Toxicity/Hartmut Engelmann et al. J. Biol. Chem. 264: 11974-11980, 1989.
Purification and Biologic Characterization of a Specific Tumor Necrosis Factor a Inhibitor Philippe Seckinger et al. J. Bio. Chem., 264: 11966-11973, 1989.
A Tumor Necrosis Factor Binding Protein is present in human biological fluids Christina Peetre et al., Eur. J. Haem., 41: 414-419, 1988.
Philippe Seckinger et al. J. Biol. Chem. 264: 11966-11973, 1989.
A Tumor Necrosis Factor Binding Protein is present in human biological fluids, Christina Peetre, et al. Eur. J. Haem., 41:414-419, 1988.
Dembinski Wlodzimierez E.
Ip Margot
Guest Shelly J.
Health Research , Inc.
Lacey David L.
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