TNF inhibition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548550, 548551, A61K 3140

Patent

active

055479790

ABSTRACT:
Derivatives of 2-pyrrolidinones are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production.

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Renz et al., J. Immunol., Release of Tumor Necrosis Factor-.alpha.From Macrophages, vol. 141(7), 2388-2393 (1988).

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