TNF-.alpha. ribozymes and derivatives capable of decreasing degr

Details TNF-.alpha. ribozymes and derivatives capable of decreasing degr TNF-.alpha. ribozymes and derivatives capable of decreasing degr

1995-04-04

2000-03-21

Brusca, John S.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 911, 4353201, 435325, 536 231, 536 232, 536 241, 536 245, C12P 1934, C07H 2104, C12N 1585, C12N 120

Patent

active

060401591

ABSTRACT:
This invention describes compounds active against TNF-.alpha. mRNA. It further describes mRNA molecules capable of conferring stability to RNA in vivo. Possible mRNA molecules to be stabilized include ribozymes, antisense molecules and mRNA encoding polypeptides useful for protein production. The ribozymes and antisense molecules described herein are useful in mammals and plants, particularly suited for viral diseases. Methods of production and methods of use are also described.

REFERENCES:
patent: 4666848 (1987-05-01), Gelfand et al.
patent: 5107065 (1992-04-01), Shewmaker et al.
patent: 5149635 (1992-09-01), Gillies
patent: 5254678 (1993-10-01), Haseloff et al.
Baralle, F.E. (1983) The Functional Significance of Leader and Trailer Sequences in Eukaryotic mRNAs. International Rev. of Cytology 81:71-106.
Beutler, B. and Cerami, A. (1989) The Biology of Cachectin/TNF-A Primary Mediator of the Host Response. Ann. Rev. Immunol. 7:625-655.
Elela, S.A. and Nazar, R.N. (1992) Extended Secondary Structure as a Basis of Increased RNA Stability in a thermophilic alga Cyanidium caldarium. Biochimica et Biophysica Acta. 130:339-342.
Haseloff, J. and Gerlach, W.L. (1988) Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities. Nature 334:585-591.
Hsu, Y.-P. and Schimmel, P. (1984) Yeast LEU1. J. Biol. Chem. 259(6):3714-3719.
Nielsen, D.A. and Shapiro, D.J. (1990) Insights into Hormonal Control of Messenger RNA Stability. Mol. Endo. 4(7):953-957.
Perreault, J. et al. (1990) Mixed deoxyribo-and ribo-oligonucleotides with catalytic activity. Nature 344:565-567.
Proudfoot, N.J. and Brownlee, G.G. (1976) 3' Non-coding Region Sequences in Eukaryotic Messenger RNA. Nature 263:211-214.
Ross, H.J. et al. (1991) Cytokine Messenger RNA Stability is Enhanced in Tumor Cells, Blood 77(8):1787-1795.
Rossi, J.J. et al. (1992) Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems. AIDS Research and Human Retroviruses 8(2):183-189.
Saini, K.S. et al. (1990) Molecular Events Regulating Messenger RNA Stability in Eukaryotes. Mol. and Cell. Biochem. 96:15-23.
Shaw, G. and Kamen, R. (1986) A Conserved AU Sequence from the 3' Untranslated Region of GM-CSF mRNA Mediates Selective mRNA Degradation. Cell 46:659-667.
Sioud, M. and Drlica, K. (1991) Prevention of Human Immunodeficiency Virus Type I Integrase Expression in Escherichia coli by a Ribozyme. Proc. Natl. Acad. Sci. U.S.A. 88:7303-7307.
Sioud, M. et al. (1992) Preformed Ribozyme Destroys Tumor Necrosis Factor mRNA in Human Cells. J. Mol. Biol. 223:831-835.
Zaret, K.S. and Sherman, F. (1984) Mutationally Altered 3' Ends of Yeast CYC1 mRNA Affect Transcript Stability and Translational Efficiency. Mol. Biol. 176:107-135.
Grosshans and Cech, (1991) "A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification." Nucleic Acid Research, 19(14):3875-3880.
Kisich, K.O. and Erickson, K.L., (1991) "Anti-tumor necrosis factor-a mRNA within mammalian cells." Journal of Leukocyte Biology, Supp.2, p.70.
Cotten, Matt, (1990) "The in vivo application of ribozymes," Elsevier Science Publishers Ltd., 8(7):174-178.
Sioud et al. (1992) J. Mol. Biol. vol. 223: 831-835.
Sioud et al. (1992) Scandinavian J. Immun. vol. 36(4): 640.
Kisich et al. (1991) J. Leukocyte Biol. vol. 50(Suppl): 70.
Pennica et al. (1984) Nature vol. 312: 724-729.

Affiliated with

Also associated with

Rating

TNF-.alpha. ribozymes and derivatives capable of decreasing degr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with TNF-.alpha. ribozymes and derivatives capable of decreasing degr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TNF-.alpha. ribozymes and derivatives capable of decreasing degr will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-729587