TNF-.alpha. ribozymes

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 9131, 4351723, 4353201, 435325, 536 231, 536 232, 536 245, 514 44, C12N 1585, C12Q 168

Patent

active

058113002

ABSTRACT:
Enzymatic RNA molecules which cleave TNF-.alpha. mRNA.

REFERENCES:
patent: 4987071 (1991-01-01), Cech
patent: 5168053 (1992-12-01), Altman et al.
patent: 5334711 (1994-08-01), Sproat et al.
Stall et al. Pharm Res. 12:465-483 1995.
Baringa, "Ribozymes: Killing the Messenger," Science 262:1521-1514 (1993).
Berzal-Herranz et al., "Essential nucleotide sequence and secondary structure elements of the hairpin ribozyme," EBMO J. 12:2567-2574 (1993).
Beutler et al., "Identity of tumour necrosis factor and the macrophage-secreted factor cachectin," Nature 316:552-554 (1985).
Cech, "Ribozymes and Their Medical Implications," JAMA 260:3030-3034 (1988).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589 (1992).
Chowrira and Burke, "Extensive Phsophorothioate Substitution Yields Highly Active and Nuclease-Resistant Hairpin Ribozymes," Nucleic Acids Res. 20:2835-2840 (1992).
Collins et al., "Nucleotide Sequences For the Gene Junctions of Human Respiratory Syncytial Virus Reveal Distinctive Features of Intergenic Structure and Gene Order," Proc. Natl. Acad. Sci. USA 83:4594-4598 (1986).
Collins and Olive, "Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neurospora VS RNA," Biochemistry 32:2795-2799 (1993).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Fauci, "Cytokin Regulation of HIV Expression," Lymphokine Res. 9:527-531 (1990).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Res. 21:2867-2872 (1993).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849-857 (1983).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28:4929-4933 (1989).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA", Nucleic Acids Research 18:299-304 (1990).
Harris et al., "Rheumatoid Arthritis: Pathophysiology and Implications for Therapy," N. Engl. J. Med. 332:1277-1289 (1990).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Hertel et al., "Numbering System for the Hammerhead," Nucleic Acids Res. 20:3252 (1992).
Hession et al., WO 9013300 (Nov. 15, 1990) provided as CA Abstr. Acc#114(25): 292037g.
Jaeger et al., "Improved Predictions of Secondary Structures for RNA," Proc. Natl. Acad. Sci. USA 86:7706-7710 (1989).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Johnston and Hoth, "Present Status and Future Prospects for HIV Therapies," Science 260:1286-1293 (1993).
Descamps-Latscha et al., "Increased Plasma Levels of Soluble CD23 in Patients with End Stage Chronic Renal Failure," J. Leukocyte Biol. Sup. 2:70 (1991).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
Kim et al., Proc. Natl. Acad. Sci. USA 84:788 (1987).
Kisich et al., "Anti-Tumor Necrosis Factor-.alpha. Ribozymes Specifically Cleave NBative mRNA AMong TotalCellular RNa in Vitro," FASEB J 4:A 1860 at 970 (1990) (abstract).
Kriegler et al., "A Novel Form of TNF/Cachectin is a Cell Surface Cytotoxic Transmembrane Protein: Ramifications for the Complex Physiology of TNF," Cell 53:45-53 (1988).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Leads to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," Embo J. 11:4411-4418 (1992).
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy for Gene Therapy in AIDS," Proc. Natl. Acad. Sci. U.S.A. 90:8000-8004 (1993).
Mamone et al., "Design of Hammerhead Ribozymes Targeted to Sequences in HIV, HSV and the RAT ANF Gene," Abstract of Keystone, CO (May 27, 1992).
Milligan and Uhlenbeck, "Synthesis of Small RNAs Using T7 RNA Polymease," Methods Enzymol, 180:51-62 (1989).
Nabel et al., "Site-Specific Gene Expression in Vivo by Direct Gene Transfer Into the Arterial Wall," Science 249:1285-1288 (1990).
Ohkawa et al., "Activities of HIV-RNA Targeted Ribozymes Transcribed From a `Shot-Gun` Type Ribozyme-trimming Plasmid," Nucleic Acids Symp. Ser. 27:15-16 (1992).
Ojwang et al., "Inhibition of Human Immunodeficiency Virus Type 1 Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Old, "Tumor Necrosis Factor (TNF)," Science 230:4255-4231 (1985).
Parillo et al., "Pathogenetic Mechanisms of Septic Shock," N. Eng. J. Med. 328:1471-1477 (1993).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA," Abstract of Keystone, CO (May 27, 1992).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .epsilon. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Rossi et al, "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:183 (1992).
Rossi et al., "Ribozyme Mediated Intracellular Immunity to HIV-1 in CD4," J. Cell Biochem. Suppl 14A:D428 (1990).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222-1225 (1990).
Sarver et al., "Catalytic RNAs (Ribozymes): A New Frontier in Biomedical Applications," AIDS Res. Revs. 2:259 (1992).
Saville and Collins, "RNA-Mediated Ligation of Self-Cleavage Products of a Neurospora Mitochondrial Plasmid Transcript," Proc. Natl. Acad. Sci. USA 88:8826-8830 (1991).
Scanlon et al., "Ribozyme-Mediated Cleavage of c-fos mRNA Reduces Gene Expression of DNA Synthesis Enzymes and Metallothionein," Proc. Natl. Acad. Sci. USA 88:10591-10595 (1991).
Scaringe et al., "Chemical synthesis of biologically active oligoribonucleotides using .beta.-cyanoethyl protected ribonucleoside phosphoramidites," Nucl Acids Res. 18:5433-5441 (1990).
Shakhov et al., ".sub.K B-Type Enhancers are Involved in Lipopolysaccharide-Mediated Transcriptional Activatio of the Tumor Necrosis Factor .alpha. Gene in Primary Macrophages," J. Exp. Med. 171:35-47 (1990).
Smith, "A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins," Science 248:1019-1023 (1990).
Sioud et al., J. Mol. Biol. 223:831-835 (1992).
Taira et al., "Construction of a novel RNA-transcript-trimming plasmid which can be used both in vitro in place of run-off and (G)-free transcriptions and in vivo as multi-sequences transcription vectors," Nucleic Acids Research 19:5125-5130 (1991).
Tanabe et al., J. Biol. Chem. 262:16580 (1987), provided as BIOSIS Abstr. 85047487.
Tracey and Cerami, "Tumor Necrosis Factor in the Malnutrition (Cachexia) of Infection and Cancer," Am. J. Trop. Med. Hyg. 47:2-7 (1992).
Turestskaya et al., "Genomic Structure, Induction, and Production of TNF-.beta.," Tuumor Necrosis Factor: Structure Function and Mechanism of Action, BB Aggarwal, J. Vilcek, Eds. Marcel Dekker, Inc. pp. 35-60 (1991).
Uhlenbeck, "A Small Catalytic Oligoribonucleotide," Nature 328:596-600 (1987).
Perreault et al., "Mixed Deoxyribo-and Ribo Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Usman and Cedergren, "Exploiting the chemical synthesis of RNA," TIBS 17:334-339 (1992).
Usman et al., "Automated Chemical Synthesis of Long O

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

TNF-.alpha. ribozymes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with TNF-.alpha. ribozymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TNF-.alpha. ribozymes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1621303

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.