Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1998-10-30
2000-01-11
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 4, 435219, 435226, C12Q 137
Patent
active
060134666
ABSTRACT:
A metalloprotease that converts TNF-.alpha. from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
REFERENCES:
patent: 5830742 (1998-11-01), Black et al.
Mohler et al., Nature, vol. 370, pp. 218-220, Jul. 21, 1994.
Davies B, et al. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts, Cancer Res., 1993, vol. 53, pp. 2087-2091, May 1, 1997.
Moss ML, et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature., 1997, vol. 385, pp. 733-736, Feb. 20, 1997.
Amour A, et al. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett., 1998, vol. 435, pp. 39-44, Sep. 11, 1998.
Black Roy A.
Cerretti Douglas P.
March Carl J.
Rauch Charles
Achutamurthy Ponnathapu
Immunex Corporation
Kirschner Michael K.
Mayhew Bradley S.
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