Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-06-28
2005-06-28
Jones, W. Gary (Department: 1655)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100
Reexamination Certificate
active
06911306
ABSTRACT:
The invention relates to the identification of a novel gene, TMS1, which is transcriptionally silenced as a result of methylation. Nucleic acids and polypeptides are provided as are methods and tools for diagnosing and treating disorders characterized by such methylation, and/or abnormally low levels of TMS1 expression products.
REFERENCES:
patent: 5552277 (1996-09-01), Nelson et al.
patent: 5756668 (1998-05-01), Baylin et al.
patent: 5786146 (1998-07-01), Herman et al.
patent: 6369196 (2002-04-01), Bertin
patent: WO96/35704 (1996-11-01), None
patent: WO 99/47669 (1999-09-01), None
patent: WO01/00826 (2001-01-01), None
Dermer, Gerald. “Another Anniversary for the War on Cancer”. Bio/Technology. vol. 12, Mar. 1994, p. 320.
GenBank Submission; NIH/NCBI; Accession No. AF184072; Vertino, P.M.; Feb. 2, 2001.
GenBank Submission; NIH/NCBI; Accession No. AF184073; Vertino, P.M.; Feb. 2, 2001.
GenBank Submission; NIH/NCBI; Accession No. AF255794; Vertino, P.M.; Feb. 2, 2001.
GenBank Submission; NIH/NCBI; Accession No. AB032249; Masumoto, J., et al.; May 8, 2001.
GenBank Submission; NIH/NCBI; Accession No. AB023416; Masumoto, J., et al.; Oct. 18, 2000.
GenBank Submission; NIH/NCBI; Accession No. NM_013258; Masumoto, J., et al.; Nov. 2, 2000.
Conway, et al., “TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers”,Cancer Res., 60(22):6236-42 (2000). Abstract.
Conway, et al., “Identification of novel downstream targets of methylation-mediated gene inactivation”,Proc. Amer. Assoc. Cancer Res., 40:321 Publisher American Association for Cancer Research (215) 440-9300—Poster Presentation Apr. 1999.
Vertino, et al., “De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (Cystosine-5-) -methyltransferase”,Mol. Cell. Biol., 16(8):4555-4565 (1996).
Masumoto, et al., “ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells”,J. Biol. Chem., 274(48):33835-33838 (1999).
Katzenellenbogen, et al., “Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies”,Blood, 93(12):4347-53 (1999)ABSTRACT.
Bachman, et al., “Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain and other human cancers”,Cancer Res., 59(4):798-802ABSTRACT.
Esteller, et al., “Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia”,Cancer Res., 59(4):793-7 (1999)ABSTRACT.
Esteller, et al., “Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in humanneoplasia”,Cancer Res., 58(20):4515-8 (1998)ABSTRACT.
Herman, et al., “Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma”,Proc. Natl. Acad. Sci., 95(12):6870-5 (1998)ABSTRACT.
Herman, et al., “Methylation-specific PCR:a novel PCR assay for methylation status of CpG islands”,Proc. Natl. Acad. Sci., 93(18):9821-6 (1996)ABSTRACT.
Graff, et al., “E-cadherin expression is silenced by DNA hypermethylation in human breast and prostrate carcinomas”,Cancer Res., 55(22):5195-9 (1995)ABSTRACT.
Merlo, et al., “5′CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers”,Nat. Med., 1(7):686-92 (1995)ABSTRACT.
Herman, et al., “Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma”,Proc. Natl. Acad. Sci., 91(21):9700-4 (1994)ABSTRACT.
Silva, et al., “Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients”,Br. J. Cancer, 80(8):1262-4 (1999)ABSTRACT.
Engelman, et al., “Sequence and detail organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1) . . . ”FEBS Lett., 448(2-3):221-30 (1999)ABSTRACT.
Catteau, et al., “Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics”,Oncogene, 18(11):1957-65 (1999)ABSTRACT.
Yu, et al., “NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas”,Proc. Natl. Acad. Sci._USA, 96(1):214-9 (1999)ABSTRACT.
Magdinier, et al., “Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region”,Oncogene, 17(24):3169-76 (1998)ABSTRACT.
Lapidus, et al, “Methylation of estrogen and progesterone receptor gene 5′ CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors”,Clin. Cancer. Res., 2(5):805-10 (1996)ABSTRACT.
Rice, et al., “Aberrant methylation of the BCRA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells”Oncogene, 17(14):1807-12 (1998)ABSTRACT.
Huschtscha, et al., “Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells”,Cancer Res., 58(16):3508-12 (1998)ABSTRACT.
Jhaveri, et al., “Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells”,Gene, 210(1):1-7 (1998)ABSTRACT.
Fujii, et al., “Methylation of the HIC-1 candidate tumor suppresor gene in human breast cancer”,Oncogene, 16(16):2159-64 (1998)ABSTRACT.
Foster, et al., “Inactivation of p16 in human mammary epithelial cells by CpG island methylation”,Mol. Cell. Biol., 18(4):1793-801 (1998)ABSTRACT.
Wicki, et al., “Repression of the candidate tumor suppressor genes S100A2 in breast cancer is mediated by site-specific hypermethylation”,Cell Calcium, 22(4):243-54 (1997)ABSTRACT.
Dobrovic, et al., “Methylation of the BRCA1 gene is sporadic breast cancer”,Cancer Res., 57(16):3347-50 (1997)ABSTRACT.
Huynh, et al., “Silencing of the mammary-derived growth inhibitor (MDGI) gene in breast neoplasms is associated with epigenetic changes”,Cancer Res., 56(21):4865-70 (1996)ABSTRACT.
Herman, et al., “Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B”,Cancer Res., 56(4):722-7 (1996)ABSTRACT.
Herman, et al., “Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers”,Cancer Res., 55(20):4525-30 (1995)ABSTRACT.
Ottaviano, et al., “Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells”,Cancer Res., 54(10):2552-5 (1994)ABSTRACT.
MacConnell, et al., “TMS1, a novel apoptosis-inducing protein that is silenced by methylation in breast cancer cells” Proceedings of the American Association For Cancer Research, Mar. 2000, vol. 41, p. 464, 91stAnnual Meeting of the American Association for Cancer Research; San Francisco, CA, USA; Apr. 1-5, 2000.
Vertino, et al., “Identification of novel targets of methylation-mediated gene silencing: Loss of apoptotic signalling by aberrant methylation” Proceedings of the American Association For Cancer Research, Mar. 2000, vol. 41, p. 896, 91stAnnual Meeting of the American Association for Cancer Research; San Francisco, CA, USA; Apr. 1-5, 2000 Abstract S37.
MacConnell, et al., “Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1” Cancer Res. 2000, vol. 60, No. 22, pp. 6243-6247.
Levine, et al., “High-resolution methylation mapping of the TMS1 locus in human breast cancer cell lines and primary tumors” Proceedings of the American Association For Cancer Research., Mar. 2001, vol. 42, pp. 708-709, 92ndAnnual Meeting of the American Association
Emory University
Goldberg Jeanine
Jones W. Gary
Wolf Greenfield & Sacks P.C.
LandOfFree
TMS1 compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with TMS1 compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TMS1 compositions and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3522267