TMPRSS2 is a tumor suppressor

Details TMPRSS2 is a tumor suppressor TMPRSS2 is a tumor suppressor

1999-06-29

2000-12-26

Johnson, Nancy A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 1, 536 187, 536 221, 536 231, C07H 2100, C07H 2102, C07H 2104, C12N 1500, C12N 1512

Patent

active

061661945

ABSTRACT:
The present invention relates to the relation of the TMPRSS2 gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the TMPRSS2 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

REFERENCES:
patent: 5359047 (1994-10-01), Donahue et al.
patent: 5710001 (1998-01-01), Skolnick et al.
Nucleic acid database, Accession #U75329, 1997.
Mollenhauer, J., et al. "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors", Nature Genetics, Sep. 1997; 17:32-39.
Paoloni-Giacobino, A., et al. "Cloning of the TMPRSS2 Gene, Which Encodes a Novel Serine Protease with Transmembrane, LDLRA, and SRCR Domains and Maps to 21q22.3", Genomics, 1997; 44:309-320.
Resnick, D., et al. "The SRCR superfamily: a family reminiscent of the lg superfamily", Trends Biochem. Sci., Jan. 1994; 19:5-8.
Whitney, G.S., et al. "The Membrane-proximal Scavenger Receptor Cysteine-rich Domain of CD6 Contains the Activated Leukocyte Cell Adhesion Molecule Binding Site", J. Biol. Chem., Aug. 4, 1995; 270(31):18187-18190.

Affiliated with

Also associated with

Rating

TMPRSS2 is a tumor suppressor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with TMPRSS2 is a tumor suppressor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TMPRSS2 is a tumor suppressor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-996408