Chemistry: physical processes – Physical processes – Crystallization
Patent
1974-07-12
1976-06-15
Wolk, Morris O.
Chemistry: physical processes
Physical processes
Crystallization
23253TP, 73 611C, 210 31C, B01D 1508, G01N 3108, G01N 3316
Patent
active
039634213
ABSTRACT:
A simplified method of carrying out thin-layer chromatography for the detection of drugs. Neutral, basic amine-containing, and acidic drugs are extracted from a physiological medium with a salt-organic solvent system. The organic phase is then transferred incrementally to a small dish having a small adsorbent disc, with the organic solvent system evaporated between the incremental additions. When the organic extractant is substantially completely evaporated, the disc is then introduced into an available opening adjacent one end of a thin-layer chromatograph. The chromatograph is then developed employing a developing solution. After drying the chromatograph, the chromatograph is subjected to specific reagent treatment and developing processes, involving dipping, rather than spraying, to color the various spots and make them visible. In this manner, a physiological sample can be rapidly treated and the presence of a drug determined in accordance with its migration and coloration under reagent treatment.
REFERENCES:
patent: 3275416 (1966-09-01), Zaar
patent: 3540850 (1970-11-01), Halpaap
patent: 3714035 (1973-01-01), Jones
patent: 3832134 (1974-08-01), Sohn
"Isolation & Identification of Drugs," E. G. C. Clarke, ed., pp. 16-30, Pharmaceutical Press, London, 1969.
Marantz Sidney
Sierra Laboratories, Inc.
Wolk Morris O.
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