Tissue-specific transporter inhibitor

Details Tissue-specific transporter inhibitor Tissue-specific transporter inhibitor

2008-09-02

2008-09-02

Rao, Manjunath (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C424S078080, C424S078180, C424S078190, C536S001110

Reexamination Certificate

active

10742335

ABSTRACT:
The present invention is to provide a tissue-specific transporter inhibitor which is not absorbed through the digestive tract and can prevent deterioration in the QOL of a patient caused by diet therapy, and a therapeutic drug for tissue dysfunction diseases and a therapeutic drug for suppressing the progress of chronic renal failure containing the inhibitor as an active ingredient. A tissue-specific transporter inhibitor which is not absorbed through the digestive tract is constructed by introducing a dipeptide which is a ligand of an oligopeptide transporter 1 into a supramolecular structure polyrotaxane wherein its structurally modified active residue is expected to be excellent in the interaction with a transmembrane transporter.

REFERENCES:
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