Chemistry: molecular biology and microbiology – Vector – per se
Patent
1994-12-23
1998-11-10
Campbell, Bruce R.
Chemistry: molecular biology and microbiology
Vector, per se
4351723, 536 241, 935 22, 935 36, C12N 1500, C07H 2104
Patent
active
058343067
ABSTRACT:
Methods and compositions relating to chimeric genes containing (i) a tissue-specific promoter and (ii) a hypoxia response enhancer element, both of which are operably linked to a selected gene, such as a reporter gene, therapeutic gene (e.g., bcl-2, NOS, catalase and SOD), or deleterious gene are disclosed. Expression of the selected gene is enhanced in the target tissue under hypoxic conditions, such as conditions encountered during episodes of ischemia and reperfusion. The methods and compositions may be used as therapeutics and/or diagnostics.
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Bishopric Nanette H.
Webster Keith A.
Campbell Bruce R.
SRI - International
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