Tissue specific hypoxia regulated constructs

Details Tissue specific hypoxia regulated constructs Tissue specific hypoxia regulated constructs

1997-06-23

2001-04-17

LeGuyader, John L. (Department: 1633)

Chemistry: molecular biology and microbiology

Vector, per se

C435S325000, C435S455000, C536S023100, C536S024100

Reexamination Certificate

active

06218179

ABSTRACT:

FIELD OF THE INVENTION
This invention relates to chimeric genes (e.g., carried on expression vectors) containing therapeutic genes whose expression is under the control of tissue specific and hypoxia response enhancer elements.
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BACKGROUND OF THE INVENTION
Each year, over a half-million Americans die from heart attacks. Even more—close to 700,000—have non-fatal heart attacks. For these surviving victims, a portion of the heart is usually damaged irreparably. Such cell death of cardiac tissue, called myocardial infarction, is due in large part to tissue damage caused by ischemia and/or ischemia followed by reperfusion.
Similar ischemic damage may occur in many other tissues when the blood supply to the tissue is reduced or cut off. Stroke, deep vein thrombosis, pulmonary embolus, and renal failure are examples.
Surviving vi

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