Tissue specific expression of exogenous proteins in...

Details Tissue specific expression of exogenous proteins in... Tissue specific expression of exogenous proteins in...

2008-01-29

2008-01-29

Kaushal, Sumesh (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S008000, C800S021000, C800S025000, C435S320100, C435S325000, C435S455000

Reexamination Certificate

active

10216098

ABSTRACT:
Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white.

REFERENCES:
patent: 6287863 (2001-09-01), Hodgson
patent: 6825396 (2004-11-01), MacArthur
patent: 2002/0028488 (2002-03-01), Singh et al.
patent: WO 99/19472 (1999-04-01), None
patent: WO 00/44892 (2000-01-01), None
patent: WO 00/11151 (2000-03-01), None
patent: WO 00/75300 (2000-06-01), None
patent: WO 02/12437 (2002-02-01), None
Ivarie, Avian transgenesis: progress towards the promise. Trends Biotechnol. 21(1):14-9, 2003.
Harvey et al, Expression of exogenous protein in the egg white of transgenic chickens. Nat Biotechnol.20(4):396-9 2002.
Zhu et al, Production of human monoclonal antibody in eggs of chimeric chickens. Nat Biotechnol. 23(9):1159-69. 2005.
Gaub et al EMBO 6(8):2313-2320, 1987.
Dierrich et al EMBO 6(8)2305-2312, 1987.

Affiliated with

Also associated with

Rating

Tissue specific expression of exogenous proteins in... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tissue specific expression of exogenous proteins in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue specific expression of exogenous proteins in... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3935994