Tissue-specific enhancer active in prostate

Details Tissue-specific enhancer active in prostate Tissue-specific enhancer active in prostate

1994-01-13

1998-11-03

Stone, Jacqueline M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4353201, 536 241, C12N 1500, C12N 1585, C12N 1563, C07H 2104

Patent

active

058306862

ABSTRACT:
The invention provides a human prostate-specific transcriptional regulatory sequence, polynucleotides comprising such regulatory regions, toxin gene constructs wherein a toxin gene is expressed under the transcriptional control of a human prostate-specific transcriptional regulatory sequence, and methods for treating prostate disease using such toxin gene contructs.

REFERENCES:
Nabel, GJ et al., Human Gene Therapy, 3:399-410 (1992).
Maxwell, IH et al., Cancer Research, 46:4660-4664 (1986).
Riegman, PHJ et al., Molecular Endocrinology, 5(12):1921-1930(1991).
Riegman, PHJ et al., Genomics, 14:6-11 (1992).

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