Tissue-specific and target RNA-specific ribozymes

Details Tissue-specific and target RNA-specific ribozymes Tissue-specific and target RNA-specific ribozymes

1995-11-08

1998-10-20

Elliott, George C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4353201, 536 245, C12P 1934, C12N 1511, C07H 2102

Patent

active

058245197

ABSTRACT:
The invention provides tissue-specific and target RNA-specific ribozymes. These ribozymes can be used to destroy target-specific neoplasms and to treat viral infections, among other uses. The ribozymes of the present invention comprise a 5' autocatalytically cleaving ribozyme sequence, a catalytic ribozyme comprising a target RNA-specific binding site and a 3' autocatalytically cleaving ribozyme. The invention also provides nucleic acids which encode the ribozymes of the invention. These nucleic acids can be used to express the ribozymes of the invention at the selected site. Methods of treating disease by administering the ribozymes are provided.

REFERENCES:
patent: 5436330 (1995-07-01), Taira et al.
patent: 5500357 (1996-03-01), Taira et al.
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Database WPI, Section Ch, Week 9335 Derwent Publications Ltd., London, GB; Class B04, AN 93-277467, XP002026580 and JP 05 192 151 A (Agency of Ind Sci & Technology), 3 Aug. 1993 Abstract.
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Yuyama et al. "Construction of a tRNA-embedded-ribozyme trimming plasmid" Biochem. and Biophy. Res. Comm. 186(3):1271-1279, Aug. 14, 1992.
Taira et al. "Construction of a novel RNA-transcript-trimming plasmid which can be used both . . . transcription vectors" Nuc. Acids Res. 19(19)5125-5130, 1991.
Ohme-Takagi et al. In vivo RNA transcript-releasing plasmid possessing a universal . . . artificial ribozymes Nuc. Acids Symp. Ser. No. 22, 49-50, Oxford Univ. Press, Oxford, England 1990.
Taira et al. "Construction of a novel artificial-ribozyme-releasing plasmid" Protein Eng. 3(8):733-737, 1990.

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