Tissue-selective insulin analogs

Details Tissue-selective insulin analogs Tissue-selective insulin analogs

1992-07-30

1993-12-07

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

435 694, C07K 700, A61K 3726, C12P 2106

Patent

active

052684539

ABSTRACT:
Human insulin analogs are disclosed. These analogs are tissue-selective. Accordingly, pharmaceutical formulations containing the analogs of the invention provide superior clinical benefits as compared to human insulin when used in the treatment of patients suffering from diabetes. The analogs are modified at amino residue A12, A15 or A19, are different from the naturally occurring residue at said position, and are hepatoselective. Also disclosed are human insulin analogs modified at amino acid residues A12 or A14 or amino acid residues A10 and A13 different from naturally occurring residues or residues at said position or positions and are peripheral selective. DNA sequences and microorganisms comprising sequences coding for human insulin analogs are also provided. Processes for preparing the human insulin analogs are described.

REFERENCES:
Podlecki et al. 1983 Diabetes 32:697.
Tompkins et al. 1981 Drabetologia 20:94-101.

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