Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1997-03-10
1998-06-30
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 911, 436500, 5303981, 536 221, C12P 1934, G01N 3353, C07H 2102, C07H 2104
Patent
active
057732590
ABSTRACT:
The invention relates to a method of diagnosing artherosclerosis by detecting mutation or altered expression of HC gp-39.
REFERENCES:
patent: 4965188 (1990-10-01), Mullis et al.
Nyirkos, Peter & Golds, E.E.; Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during thr non-lactating period; Biochemistry (1990); vol. 269; pp. 265-268.
Johansen, J.S., Jensen, H.S. Price, P.A.; A New Biochemical Marker for Joint Injury. Analysis of YKL-40 in Serum and Synovial Fluid; British Journal for Rhematology 1993; vol. 32; No. 11; pp. 949-955.
Rejman, J.J., Hurley, W.L.; Isolation and Characterization of a Novel 39 Kilodalton Whey Protein from Bovine Mammary Secretions Collected During the Nonlactating Period; Biochemical and Biophysical Research Communications; Jan. 15, 1988; vol. 150, No. 1; pp. 329-334.
Kirkpatrick, Robert B., Matico, R.E., McNulty, D.E., Strickler, J.E., Rosenberg, M.; An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages; Gene 153 (1995); pp. 147-154.
Johansen, J.S., Cintin, C., Jorgensen, M., Kamby, C., Price, P.A.; Serum YKL-40: a New Potential Marker of Prognisis and Location of Metastases of Patients with Recurrent Breast Cancer; European Journal of Cancer; 1995; vol. 31A; No. 9; pp. 1437-1442.
Johansen, J.S., Williamson. M.K., Rice, J.S., Price P.A.; Identification of Proteins Secreted by Human Osteoblastic Cells in Culture; Journal of Bone and Mineral Research; vol. 7; No. 5; 1992; pp. 501-512.
Shackelton, L. M., Mann, D.M., Millis, Albert J.T.;Identification of a 38-kDa Heparin-binding Glycoprotein (gp38k) in Differentiating Vascular Smooth Muscle Cells as a Member of a Group of Proteins Associated with Tissue Remodeling; Journal of Biochemistry; vol. 270; No. 22; Issue of Jun. 2, 1995; pp. 13076-13083.
Hakala et al. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian memeber of a chitinase protein family, J. Biol. Chem. vol. 268(4), pp. 25803-25810, 1993.
Han William T.
Horlick Kenneth R.
King William T.
Lentz Edward T.
SmithKline Beecham Corporation
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