Tissue rejection

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200

Reexamination Certificate

active

07666596

ABSTRACT:
This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection.

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Sarwal M. et al ‘Molecular Heterogeneity in Acute Renal Allograft Rejection Identified by DNA Microarray Profiling’ NEJM Jul. 10, 2003, 349;2, pp. 125-138.
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Famulski et al., “Changes in the Transriptome in Allograft Rejection: IFN-γ-Induced Transcripts in Mouse Kidney Allograft,”Am. J. Transplant., 2006, 6:1342-1354.
Famulski et al., “IFN-γ inducible transcripts are increased in T cell mediated rejection but some are also increased in tissue injury,”Am. J. Transplant., 2005, 5(Suppl 11):448, Abstract.
Famulski et al., “IFN-γ acts on donor tissue to induce a signal that prevents both perforin-granzyme mediated graft destruction and alternative macrophage activation,”Am. J. Transplant., 2006, 6(Suppl 2):758, Abstract.
Famulski et al., “Heterogeneity in injury response in renal transplants: distinct patterns reflect acute phase response, cell cycle progression, genes associated with kidney development and fibrogenesis,”Am. J. Transplant., 2007, 7(Suppl 2):155, Abstract.
Halloran et al., “Interferon-γ is the principal determinant of the phenotype of T cell mediated kidney allograft rejection,”Am. J. Transplant., 2007, 7(Suppl 2):325, Abstract.
Sis et al., “A novel role for donor class I proteins: protection of kidney allografts against early necrosis and alternative macrophage activation,”Am. J. Transplant., 2006, 6(Suppl 2):759, Abstract.
Reeve, J., et al., 10 pages Uncorrected Proof accepted for publication as “Diagnosing Rejection in Renal Transplants: A Comparison of Molecular- and Histopathology-Based Approaches,” American Journal of Transplantation, 9:1-9 (2009).

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