Tissue regeneration

Details Tissue regeneration Tissue regeneration

2005-12-08

2011-12-06

Gamett, Daniel C (Department: 1647)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

C424S422000, C424S423000, C424S602000

Reexamination Certificate

active

08071083

ABSTRACT:
The present invention relates to a method of treating a tissue defect in a human or animal body comprising the steps of implanting into said body an unseeded scaffold; allowing or effecting a wound healing response at the site of said defect; allowing said scaffold to be vascularized until a substantially sufficient fluid flow through said scaffold is assured for the transport of nutrients and/or waste products, and seeding said vascularised scaffold with a suitable population of tissue-regenerating cells.

REFERENCES:
patent: 6309635 (2001-10-01), Ingber et al.
patent: 6541022 (2003-04-01), Murphy et al.
patent: 2002/0142458 (2002-10-01), Williams et al.
Retuerto et al., Journal of Thoracic and Cardiovascular Surgery, vol. 127, Issue 4, Apr. 2004, pp. 1041-1050.
Yu et al., 2009 (Biomaterials, 30, 508-517.
Meijer et al., 2007 (PLoSMed., 4(2), 0260-0264.
Stevens et al. (Proc. Nat. Acad Sci. USA, 106(39), 16568-16573 (2009).
Anderson, “The Cellular Cascades of Wound Healing,”Wound Healing in Bone, 81-93 (2000).
Davies et al., “Histodynamics of Endosseous Wound Healing,”Bone Formation and Healing, 1-14 (2000).
Gunatillake et al., “Biodegradable Synthetic Polymers for Tissue Engineering,”European Cells and Materials9, 5, 1-16 (2003).
Hillsley et al., “Review: Bone Tissue Engineering: The Role of Interstitial Flow,”Biotechnology and Bioengineering, 43, 573-581 (1994).
Li et al., “Low-Molecular-Weight Peptides Derived from Extracellular Matrix as Chemoattractants for Primary Endothelial Cells,”Endothelium, 11, 199-206 (2004).
Nakagawa et al., “Osteoclastogenesis on Tissue-Engineered Bone,”Tissue Engineering, 10 (1/2), 93-100 (2004).
Qin et al., “Fluid Pressure Gradients, Arising from Oscillations in Intramedullary Pressure, is Correlated with the Formation of Bone and Inhibition of Intracortical Porosity,”Journal of Biomechanics, 36, 1427-1437 (2003).
Yu et al., “Bioreactor-Based Bone Tissue Engineering: The Influence of Dynamic Flow on Osteoblast Phenotypic Expression and Matrix Mineralization,”PNAS, 101 (31), 11203-11208 (2004).

Affiliated with

Also associated with

Rating

Tissue regeneration does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tissue regeneration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue regeneration will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4261020