Tissue plasminogen activator variants

Details Tissue plasminogen activator variants Tissue plasminogen activator variants

1994-09-15

1998-02-03

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 424 9464, 536 232, C12N 950, C12N 964, C12N 1555, C12N 510

Patent

active

057143722

ABSTRACT:
Biologically active mutant tissue plasminogen activators are disclosed wherein site directed mutagenesis, for example, of a two-chain activation site renders said mutants resistant to conversion to the two-chain form. In addition, mutant tissue plasminogen activators are disclosed which have amino acid substitutions or deletions in the region of positions 274-277, which may or may not be resistant to conversion to the two-chain form, but show enhanced fibrin specificity relative to wild-type tissue plasminogen activator.

REFERENCES:
patent: 4753879 (1988-06-01), Rosa et al.
patent: 4935237 (1990-06-01), Higgins et al.
patent: 5094953 (1992-03-01), Anderson et al.
Pennica, D. et al., Nature, vol. 301, pp. 214-221, 1983.
Tate, K. et al., Biochemistry, vol. 26, pp. 338-343, Jan. 1987.

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