Tissue plasminogen activator variant with deletion of amino acid

Details Tissue plasminogen activator variant with deletion of amino acid Tissue plasminogen activator variant with deletion of amino acid

1990-03-01

1992-10-20

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 435255, 4353201, 435226, 536 27, C12N 964, C12N 1558, C12N 1500, C12N 510, C07H 2104

Patent

active

051569698

ABSTRACT:
A tissue plasminogen activator (t-PA) variant is prepared that has an amino acid deletion at positions 466 to 470 of the corresponding wild-type t-PA. This alteration renders the variant fibrin (and plasma clot) specific as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the variant, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variant may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesin formation or reformation in mammals.

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