Tissue plasminogen activator modified by the substitution of Arg

Details Tissue plasminogen activator modified by the substitution of Arg Tissue plasminogen activator modified by the substitution of Arg

1988-01-29

1990-10-16

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435 692, 4351723, 435212, 435226, 4352402, 435320, 536 27, 935 10, 935 14, 935 23, 935 27, 935 70, C12N 948, C12N 1558, C12N 2102, A61K 37547

Patent

active

049633570

ABSTRACT:
A modified tissue plasminogen activator having an improved in vivo half-life characterized in that the normal protein moiety of 527 amino acids is mutated at the site Cys73.fwdarw.Arg.

REFERENCES:
patent: 4766075 (1988-08-01), Goeddel et al.
Wang, A. et al., Science, vol. 224, pp. 1431-1433, Jun., 1984.
Ny, T. et al., Proc. Natl. Acad. Sci., vol. 81, pp.5355-5359, Sep., 1984.
Pennica et al., Nature 301, 214-221 (1983).
Vehar, Bio/Technology 2(12), pp. 1051-1057 (1984).
Kagitani et al., FEBS Lett. 189(1), 145-149 (1985).
Zonneveld et al., Proc. Natl. Acad. Sci. U.S.A. 83, 4670-4 (1986).
Verheijen et al., The EMBO J. 5(13), 3525-3530 (1986).
Ehrlich et al., Fibrinolysis 1, 75-81 (1987).
Klausner, Bio/Technology 4, 706-710 (1986).
Klausner, Bio/Technology 5, 869-870 (1987).
Lau et al., Bio/Technology 5(9) 953-958 (1987).

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