Tissue plasminogen activator inhibitor and method of purificatio

Details Tissue plasminogen activator inhibitor and method of purificatio Tissue plasminogen activator inhibitor and method of purificatio

1986-05-16

1992-07-28

Doll, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435215, 435212, 435219, 435226, 530380, 530413, 530414, 530416, 530417, C12P 2100, C12N 950, C12N 972, C12N 964

Patent

active

051340658

ABSTRACT:
A novel and unique plasminogen activator inhibitor fragment is obtained from human umbilical vein endothelial cells which has the following characteristics:

REFERENCES:
patent: 3778352 (1973-12-01), Bishop et al.
patent: 4661453 (1987-04-01), Pollard
The EMBO Journal, vol. 5, No. 10, pp. 2539-2544 (1986).
Ny et al. Proc. Natl. Acad. Sci. USA, 83, 6776-6780 (1986).
Emeis et al., Biochem. Biophys. Res. Commun. 110(2), 392-398 (1983).
Scott et al., J. Biol. Chem. 260(11), 7029-7034 (1985).
Loskutoff et al., Proc. Natl. Acad. Sci. USA 80, 2956-60 (1983).
van Mourik et al., J. Biol. Chem. 259 (23), 14914-21 (1984).
Hekman et al., Ibid. 260(21), 11581-87 (1985).
Lecander et al., Brit. J. Haematol. 57, 407-12 (1984).
Astedt et al., Thromb. Haemostas, 53(1), 122-25 (1985).
Vasalli et al., J. Exp. Med. 159, 1653-68 (1984).
Levin, Proc. Natl. Acad. Sci. USA 80, 6804-08 (1983).
Sprengers et al., Biochim. Biophys. Acta 801, 163-170 (1984).
Philips et al., Ibid. 802, 99-110 (1984).
Pannekoek, J. Cell. Biochem. Supp. 10A, Absts. 15th Ann. Meeting, UCLA Symposium on Mol. & Cell. Biology, Jan. 20-Feb. 15, 1986, Abst. E119, p. 277.
Loskutoff, Ibid. Abst. E5, p. 231.
Levin, "Latent tissue plasminogen activator produced by human endothelial cells in culture: Evidence for an enzyme-inhibitor complex", PNAS, V. 80, 6804-08, 1983.
Philips et al., "Human Endothelial Cells Produce a Plasminoger Activator Inhibitor and a Tissue-Type Plasminogen Activator-Inhibitor Complex", Biochimira et Biophysica Acta, v. 802, 99-110, 1984.
Sprengers et al., "Evidence for the Presence of two Different Fibrinolytic Inhibitors In Human Endothelial Cell Conditioned Medium" Biochim. Biophys. Acta 801, 163-170, 1984.

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