Tissue plasminogen activator having fibrin specific properties a

Details Tissue plasminogen activator having fibrin specific properties a Tissue plasminogen activator having fibrin specific properties a

1991-08-13

1993-11-02

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435212, 435219, 435226, C12N 964, C12N 1558

Patent

active

052581802

ABSTRACT:
A tissue plasminogen activator (t-PA) variant is prepared that has an amino acid deletion at positions 466 to 470 of the corresponding wild-type t-PA. This alteration renders the variant fibrin (and plasma clot) specific as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the variant, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variant may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.

REFERENCES:
Tate et al., Biochemistry 26:338-343 (1987).
Peterson et al., Biochimica et Biophysica Acta 952:245-254 (1988).
Rijken et al., J. of Biol. Chem. 257:2920-2925 (1982).
Ross et al., Annual Reports in Medicinal Chemistry 23:111-120 (1988), Academic Press, Richard C. Allen, Ed.
Pannekoek et al., Fibrinolysis 2:123-132 (1988).
Huber et al., Accounts of Chemical Research 11:114-122 (1978).
Madison et al., Nature, 339:721-724 (1989).
D. Ringe, Nature, 339:658-659 (1989).

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