Tissue plasminogen activator and method of use

Details Tissue plasminogen activator and method of use Tissue plasminogen activator and method of use

1994-05-04

1996-09-17

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435212, 435226, A61K 3849, C12N 950, C12N 964

Patent

active

055566219

ABSTRACT:
The present invention relates to improved plasminogen activators (improved t-PA) which have a prolonged biological half life, an increased stability to heat and acids and can be expected to be effective as inhibiting inflammation around the site in which thrombus is formed.

REFERENCES:
patent: 4753879 (1988-06-01), Rosa et al.
patent: 4935237 (1990-06-01), Higgins et al.
patent: 5037646 (1991-08-01), Higgins
patent: 5073494 (1991-12-01), Heyneker
Tate, K. M. et al., Biochemistry, 26:338-343, 1987.

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