Tissue plasminogen activator A-chain/urokinase B-chain hybrid pr

Details Tissue plasminogen activator A-chain/urokinase B-chain hybrid pr Tissue plasminogen activator A-chain/urokinase B-chain hybrid pr

1988-02-22

1991-02-12

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9464, 435215, 435212, A61K 37547, C12N 972, C12N 948

Patent

active

049922742

ABSTRACT:
A fibrinolytically active hybrid protein which comprises one chain of a 2-chain protease linked to a chain of a different 2-chain protease, or to the same chain of the same protease, at least one of the chains in the hybrid protein being derived from a fibrinolytically active protease, such that the hybrid protein has a catalytic site essential for fibrinolytic activity which is optionally blocked by a removable blocking group.

REFERENCES:
patent: 4082612 (1978-04-01), Robbins et al.
patent: 4507283 (1985-03-01), Smith
patent: 4545988 (1985-10-01), Nakayama et al.
patent: 4600580 (1986-07-01), Smith
Summaria et al., J. Biol. Chem., vol. 254, pp. 6811-6814, 1979.
Robbins et al., Biochemistry, vol. 25, pp. 3603-3611, Jun., 1986.
Jackson et al., Biochem., 1982, 21, 6620-6625.
Summaria et al., J. Biol. Chem. 251, No. 18, 5810-5813 (1976).

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