Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-03-05
1998-11-24
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435212, 4353201, 514 12, 530 232, C12P 2102, C07H 2104, C12N 1558, C12N 1570
Patent
active
058405330
ABSTRACT:
The invention relates to a new tissue plasminogen activator which has strong activity for converting plasminogen into plasmin that degrades the fibrin network of blood clots to form soluble products and therefore is useful as a thrombolytic agent. The invention also relates to a DNA sequence encoding the amino acid sequence for the tissue plasminogen activator, to a process for producing the plasminogen activator, and to a pharmaceutical composition comprising the new tissue plasminogen activator.
REFERENCES:
patent: 5648250 (1997-07-01), Niwa et al.
van Zonneveld et al. (1986), Proc. Natl. Acad. Sci. USA, 83: 4670-4674.
Hayashi Masako
Kobayashi Masakazu
Niwa Mineo
Notani Jouji
Saito Yoshimasa
Degen Nancy
Fujisawa Pharmaceutical Co. Ltd.
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