Tissue plasminogen activator

Details Tissue plasminogen activator Tissue plasminogen activator

1995-03-29

1997-07-15

Fleischer, Mindy

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435212, 4353201, 536 232, 514 12, C12N 1570, C12N 1558, C07H 2104, A61K 3849

Patent

active

056482507

ABSTRACT:
The invention relates to a new tissue plasminogen activator which has strong activity for converting plasminogen into plasmin that degrades the fibrin network of blood clots to form soluble products and therefore is useful as a thrombolytic agent. The invention also relates to a DNA sequence encoding the amino acid sequence for the tissue plasminogen activator, to a process for producing the plasminogen activator, and to a pharmaceutical composition comprising the new tissue plasminogen activator.

REFERENCES:
van Zonneveld et al. (1986), Proc. Natl. Acad. Sci. USA 83:4670-4674.

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