Tissue-like phantoms

Details Tissue-like phantoms Tissue-like phantoms

2007-10-30

2007-10-30

Wells, Nikita (Department: 2881)

Radiant energy

Calibration or standardization methods

C250S505100, C250S506100, C378S018000, C378S207000, C600S476000, C600S478000, C600S312000, C382S131000

Reexamination Certificate

active

11222949

ABSTRACT:
The invention is based, in part, on the discovery that by combining certain components one can generate a tissue-like phantom that mimics any desired tissue, is simple and inexpensive to prepare, and is stable over many weeks or months. In addition, new multi-modal imaging objects (e.g., beads) can be inserted into the phantoms to mimic tissue pathologies, such as cancer, or merely to serve as calibration standards. These objects can be imaged using one, two, or more (e.g., four) different imaging modalities (e.g., x-ray computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and near-infrared (NIR) fluorescence) simultaneously.

REFERENCES:
patent: 2005/0145786 (2005-07-01), Rice et al.
Boehm et al., “Contrast-enhanced near-infrared laser mammography with a prototype breast scanner: feasibility study with tissue phantoms and preliminary results of imaging experimental tumors,” Invest. Radiol., 36:573-81 (2001).
Cheong et al., “A review of the optical properties of biological tissues,” IEEE J. Quantum Electronics, 26:2166-2185 (1990).
Cubeddu et al., “A solid tissue phantom for photon migration studies,” Phys. Med. Biol., 42:1971-9 (1997).
De Grand and Frangioni, “An operational near-infrared fluorescence imaging system prototype for large animal surgery,” Technol. Cancer Res. Treat., 2:553-562 (2003).
De Grand et al., “Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons,” J. Biomed. Opt., 11:014007 (2006).
English et al., “Sub-millimeter technetium-99m calibration sources,” Mol. Imag. Biol., 4: 380-384 (2002).
Frangioni, “In vivo near-infrared fluorescence imaging,” Curr. Opin. Chem. Biol., 7:626-634 (2003).
Giller et al., “Validation of a near-infrared probe for detection of thin intracranial white matter structures,” J. Neurosurg., 98:1299-306 (2003).
Jiang et al., “Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom,” J. Biomed. Opt., 8: 308-15 (2003).
Kelly et al., “Optical CT reconstruction of 3D dose distributions using the ferrous-benzoic-xylenol (FBX) gel dosimeter,” Med. Phys., 25:1741-50 (1998).
Ma et al., “Determination of complex refractive index of polystyrene microspheres from 370 to 1610 nm,” Phys. Med. Biol., 48: 4165-72 (2003).
Prahl et al., “Determining the optical properties of turbid media by using the adding-doubling method,” Appl. Opt., 32: 559-568 (1993).
Quan et al., “Glucose determination by a pulsed photoacoustic technique: an experimental study using a gelatin-based tissue phantom,” Phys. Med. Biol., 38:1911-22 (1993).
Wagnieres et al., “An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy,” Phys. Med. Biol., 42:1415-26 (1997).
Zaheer et al., “In vivo near-infrared fluorescence imaging of osteoblastic activity,” Nat. Biotechnol., 19: 1148-1154 (2001).

Affiliated with

Also associated with

Rating

Tissue-like phantoms does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tissue-like phantoms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue-like phantoms will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3903164