Tissue graft composition

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Digestive system

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623 1, 623 11, 623 12, A61K 3538, A61F 206

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active

049561782

ABSTRACT:
This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is deliminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.

REFERENCES:
patent: 3562820 (1971-02-01), Braun
patent: 4502159 (1985-03-01), Woodroff et al.
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"Replacement of the Abdominal Aorta by an Ileum Muscle Tube in an Animal Experiment", Huth, et al., Thoraxchir. Vask. Chir. 15(4):401-407, Aug. 1967.
"Use of Freely Transplanted Ileum to Replace Plastic in Cardio-Vascular Surgery", Rotthoff, et al., Langenbecks Archiv. Klin. Chir. 1964, 308, pp. 816-820.
"Replacement of the Abdominal Aorta with a Small-Intestine Muscle Tube in an Animal Experiment", J. H. Huth, Zentralbl Chir. 92 (26/2): 1817-19 (1967).
"Reconstruction of the Arterial Flow Path by Autologous Intestinal Muscle Grafts in the Dog", Bruch, et al., Folia Angiologica, vol. 29, (3-5/81), pp. 65-68.
"The Instruments of Surgery", by Francis Mitchell-Heggs and H. Guy Radcliffe Drew; William Heinemann Medical Books, Ltd., London, 1963.

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