Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1993-04-30
1998-01-20
Naff, David M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
424426, 435178, 435182, 435395, 435396, 435397, C12N 508, C12N 506, C12N 1110, C12N 1104
Patent
active
057098549
ABSTRACT:
A cell-polymeric solution is injected into an animal where the polymer crosslinks to form a polymeric hydrogel containing dispersed cells and the cells form new tissue in the animal. The polymer is biodegradable and is a natural polymer such as alginate or a synthetic polymer. The cells are chondrocytes, osteoblasts, muscle cells, fibroblasts or cells acting primarily to synthesize, secret or metabolize materials. Crosslinking of the polymer results from using cations or anions, altering the pH or changing the temperature. A polyion such as polyethyleneimine or polylysine can be added before injection to stabilize the polymeric hydrogel. A kit for tissue formation is provided by combining the cell-polymeric solution with a means for injecting the solution into an animal.
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Culliton, Barbara J., "Gore Tex Organoids
Atala Anthony
Griffith-Cima Linda
Paige Keith T.
Vacanti Charles A.
Massachusetts Institute of Technology
Naff David M.
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