Tissue factor based prothrombin time reagent

Details Tissue factor based prothrombin time reagent Tissue factor based prothrombin time reagent

1991-10-29

1994-05-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 436 69, 514 21, A61K 9127

Patent

active

053146956

ABSTRACT:
Prothrombin time reagents are provided which comprise novel liposome compositions in which tissue factor is associated with an inserted into the phospholipid bilayer of the liposomes. Methods for their preparation are also provided. The liposome compositions may be adjusted to allow maximum coagulant activity and sensitivity to extrinsic coagulation factors.

REFERENCES:
patent: 3179567 (1965-04-01), Owren
patent: 4595680 (1986-06-01), della Valle
patent: 4857319 (1989-08-01), Crowe
patent: 5017556 (1991-05-01), O'Brien
Wijngaards BBA 488, 161, 1977.

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