Tissue equivalent test systems

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

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435 1, 435283, 435284, 435289, 424 95, C12Q 102, A01N 102, A01N 6302

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active

048351024

ABSTRACT:
The present invention provides methods of, apparatus for, and kits for determining the interaction of tissue and at least one agent by use of at least one tissue equivalent. Tissue equivalent includes, but is not limited to, equivalents of epithelial tissue, connective tissue, cartilage, bone, blood, organs, glands and blood vessels, which are composed of living cells and extracellular matrix molecules, principally collagen. Agent includes, but is not limited to, various substances such as chemicals, cosmetics, pharmaceuticals, stimuli, e.g., light or physical injury; and tissue protective agents.

REFERENCES:
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patent: 4604346 (1984-10-01), Bell et al.
patent: 4629686 (1986-12-01), Gruenberg
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J. Invest. Dermatol., vol., Mar. 1975, Thomas J. Franz, Percutaneous Absorption, on the Relevance of in vitro, pp. 190-195.
Science, vol. 211, Mar. 6, 1981, Eugene Bell et al., Living Tissue Formed in vitro and Accepted as Skin Equivalent Tissue of Full Thickness, pp. 1052-1054.
J. Invest. Dermatol., vol. 81, No. 1 Supplement, July 1983, Eugene Bell et al., The Reconstruction of Living Skin, pp. 2s-10s.
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Organogenesis, Inc. Prospectus, Dec. 11, 1986; Supplemental Feb. 4, 1987.
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Scanning Electron Microscopy, vol. IV (1984) (pp. 1957-1962) Bell et al., The Living Skin-Equivalent as a Structural and Immunological Model in Skin Grafting.
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Organogenesis, Inc.--1986 Annual Report.
Securities and Exchange Commission, Form 10-K Report for fiscal year ended Dec. 31, 1986.

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