Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;...
Patent
1996-10-04
2000-05-02
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
623 12, 424426, C12N 1100, A61F 204
Patent
active
060571373
ABSTRACT:
Tissue-equivalent and biopolymer tubes and rods include fibrils which are oriented (aligned) by a magnetic field. These oriented fibrils provide enhanced mechanical and cell guidance properties to the tissue-equivalent and biopolymer tubes. One such tissue-equivalent tube includes a body of collagen gel with mammalian tissue cells interspersed therein. The collagen fibrils are circumferentially oriented within the tubular body by a magnetic field, thereby inducing circumferential orientation of the cells. One such biopolymer rod includes collagen fibrils longitudinally oriented along the rod axis by a magnetic field that guides invasion of cells. Methods of making magnetically oriented tissue-equivalent and biopolymer tubes and rods are also disclosed.
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Girton Timothy Sanuel
Guido Stefano
Mooradian Daniel L.
Tranquillo Robert T.
Regents of the University of Minnesota
Saucier Sandra E.
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