Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...
Reexamination Certificate
2001-08-21
2009-12-22
Huynh, Phuong (Department: 1644)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Solid support and method of culturing cells on said solid...
C435S366000, C435S007210, C530S816000, C424S009322, C424S193100, C424S195110
Reexamination Certificate
active
07635592
ABSTRACT:
Matrix-enhancing molecules, such as TGF-β, are conjugated to or immobilized on scaffolds to increase ECM production by cells for tissue engineering, tissue regeneration and wound healing applications. The matrix-enhancing molecule is conjugated to a tether, such as polyethylene glycol (PEG) monoacrylate, for attachment to a tissue engineering or cell growth scaffold. The matrix-enhancing molecule retains activity after attachment to the scaffold, and causes cells growing in or on the scaffold to increase extracellular matrix (ECM) production, without substantially increasing proliferation of the cells, even when the scaffold additionally contains cell adhesion ligands. The increased ECM produced by the cells aids in maintaining the integrity of the scaffold, particularly when the scaffold is degradable, either by hydrolysis or by enzymatic degradation.
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PCT International Preliminary Examination Report mailed Mar. 4, 2003.
EPO Communication pursuant to Article 96(2) EPC, dated May 24, 2004.
EPO Communication pursuant to Article 96(3) EPC, Mar. 6, 2006.
Mann Brenda K.
West Jennifer L.
Baker & Botts L.L.P.
Huynh Phuong
Rice University
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